Manual Reporting of Prohibited Substance(s) and/or Metabolite(s) of Prohibited Substance(s) Associated with an Adverse Analytical Finding (AAF) in the Lab Results [1]

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^[1] Applicable to routine doping control and EQAS samples.

Updated on 02 May 2025

1. Select from the dropdown menu the mandatory information of the substance to which the AAF is associated.
   
   
2. For Threshold Substances:
   
   • If a Threshold Substance (e.g., "methylephedrine greater than the Decision Limit") is selected, the (adjusted) Decision Limit (DL), concentration/measurement uncertainty section appears automatically, and shall be completed.
     
     
3. For Non-Threshold Substances:
   
   • If a metabolite is to be reported as part of the AAF, click Add Metabolite to detail the associated metabolite(s) confirmed and include the name of the metabolite(s) in the free-text Metabolite field. Several metabolites can be recorded for the prohibited substance by selecting the Add Metabolite function for each relevant metabolite.
4. For Non-Threshold Substances with an MRL:
   
   • Add any additional relevant information as per the TD MRPL (e.g., estimated concentration). The example below illustrates the reporting of an AAF which includes benzoylecgonine in the presence of the parent compound, cocaine. 
     
     
     
     
     
     In the above example, both cocaine and benzoylecgonine are confirmed at levels higher than (>) the corresponding MRL and reported in compliance with the TD MRPL (i.e., meeting the conditions to report an AAF for both target analytes). 
     

5. Only Metabolite(s) checkbox:

   The Only Metabolite(s) checkbox shall only be checked when it is necessary to indicate that only the reported metabolite(s), but not the parent compound itself, met the condition(s) to report an AAF. The name of the metabolite(s) shall be entered in the free-text Metabolite field.

   • The ADAMS Test Report will explicitly reflect the metabolite(s) which were recorded in ADAMS as having met the condition(s) to report an AAF (with reference to the prohibited substance).
     
     The example below illustrates the reporting of an AAF in which benzoylecgonine was confirmed at a concentration above (>) the corresponding MRL, and the parent compound, cocaine, was present at an estimated concentration below (<) the corresponding MRL. In this example, the estimated concentration of cocaine is reported, even if not reaching the MRL, for results management purposes (in accordance with the TD MRPL).
   
   
   
   
   
6. The Details Concerning Finding text field shall be used to comment on the presence or absence of other relevant prohibited substance(s) and/or metabolite(s) or markers related to the reported AAF, if relevant for results management purposes, as per relevant TD/TL. For example, the presence of cocaine at an estimated concentration below the MRL or the absence of lomerizine for trimetazidine findings.
   
   
7. Save.
   
   
8. In case the Laboratory uploads the analytical findings to ADAMS by exporting pre-define .csv or xml. files directly from the Laboratory Information Management System (LIMS), the setup of the system shall ensure that the reporting outcomes in ADAMS comply with the instructions outlined in this document.